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武汉人民医院预约时间表中华新闻

楼主:排名对话 时间:2019年06月17日 04:44:54 点击:0 回复:0
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探索世界奥秘之The Ghost In Your Genes(基因外遗传现象) 07After we had seen how relatively easy it was to change the switches in mouse embryos, we thought that perhaps the same could be true of human embryos. In IVF, you also have the embryo for a brief period of time in a culture dish. And so we were asking the question whether as in a mouse embryo, the mere fact of human embryos having been in a culture dish, or been manipulated, could alter their epigenetic switches?Wolf knew that Beckwith-Wiedemann syndrome was caused by a faulty switch. So what we were looking at was a group of babies and children that have the Beckwith-Wiedemann syndrome. What proportion of those were conceived by, by IVF. Could IVF be switching genes on or off? Could IVF itself cause the syndrome? What we found was an increased occurrence of this epigenetic syndrome in the IVF population. Although the disease is extremely rare, the risk appeared to increase three to four times with IVF. It seemed that the simple act of removing the embryo from its natural environment could trigger the disease. And, I do feel frustrated that Karen might possibly have Beckwith-Wiedemann syndrome as the, because we had IVF. But at the time, it was the right decision to make. And I think that we should look again at the IVF procedures, the conditions that are being used and carry out better and more precise experiments to see how we can avoid throwing these epigenetic switches. Wolf had shown a simple change in environment was enough to turn a gene on or off. But there was more. Everyone thought that any altered switches could not be inherited. He took some mice with altered gene switches and bred them. Our expectation was that as the altered genome was passed to the children that any epigenetic changes would be wiped clean. When he looked at the gene profile of the offspring, he was amazed. You have dots that you were looking at, and every dot means a gene is on. And all of a sudden, you know, somebody said, "Wow, Look at that".The epigenetic switch thrown in one generation was clearly also present in the second generation.200807/44961Katie Couric: Emma Watson, Good morning. Hey! Emma nice to see you.Emma Watson: Hello~Katie Couric: You know, my daughter told me the other day when they started ing the Harry Potter books at her school, all the girls thought your name was Hermi One.Emma Watson: I know, I know...I've heard so many different interpretations like oh...em... Hermio Ne, Hermi One, Her Mione...Katie Couric: But now I guess...now I guess because of the movie everyone knows how to say your name and Hermione, like Emma Watson is growing up. ("Yes.") And I think this movie reflects that, don't you? Because she's dealing with all sorts of teenage issues that are very very relatable.Emma Watson: Yeah, and she definitely is, you know that's em...this is the first film book with the introduction of romance, close teenage angst and, you've, the boys and well, the girls got to find dates for the Yule Ball and yeah..."Katie Couric: And she is sort of has...has a thing for Harry and Ron, I mean there is some sexual chemistry there and yet, they are kind of completely...out of it.Emma Watson: No, they are really not that, I think. I really think it's the Ronald , I really think he's jealous, I really think when he goes to the ball with Victor Krum, he's...he's jealous.Katie Couric: I...I think so, too. Meanwhile that, you know,we talk...I talked to Danniel about this. This movie is a little...a little darker, a little scarier than the previous ones. ("Yeah") And do you worry about that in terms of alienating fans or scaring young fans, I guess.Emma Watson: Uhm, to be honest, it's always been about staying faithful with the book, and...the book is much darker, you know, someone died, two, two people died , and there is, Voldemort's back, it's...it's gotta be darker and...and it's always been about thinking this is a book and we are older now. It's going to be more mature ,and more mature issues, and I think it's great that they actually embraced that, they haven't caught the punchies and I think they made a really great film and...yes, it is scary for younger people but em...I think we've lost younger audience as we have the gains of the adults, yeh,yeh.Katie Couric: And people who are little more mature. Meanwhile, I ,I think in a Yule Ball scene, Hermione walks down the stairs and it's such a great scene because suddenly you can see that she's really blossomed into a young lady and her...her character's forever changed in a way she's perceived, I think. It's forever changed, right?Emma Watson: Yeah, yeah. And this scene is meant to be out of a kind of real transformation. You must see her...("Kind of a Cinderella moment I have to say, Emma)Yeah,Yaeh,Yeah, exactly that. It's kind of a Julie Roberts's "Pretty Woman" ask moment where she... when you...you are like...wow...God, she's such a pretty! She's meant to look like you've never seen her before, quite different.Katie Couric: And, and I was going to ask you because because I didn't have time to talk to...to Danniel about this, but you worked with three different directors for these four movies, Chris Columbus did the first two,(Yeah.) the second one was directed by?Emma Watson: Ah.. Ah..Fo...Oh, no, Chris did the first two, and then Alfanso did the third and then...Katie Couric: Right, and now Mike Newell ,(Mike Newell too) a Four Weddings and a Funeral film, did this one. (Yeah.)Is it hard for you to...to have different visions for every director, cause I would think that would be either very exciting and challenging or like "what is this guy gonna do with it?Emma Watson: Well, Let's be honest, you know, I actually, I love it, I have to say, because...Katie Couric: I'm sure you're gonna say yeah I thought, kiddy, I mean this guy want to do with it, but..Emma Watson: No, well. No. I mean it's just er...from my point of view, you know, being in the same kind of films for four years now, it's em...it brings something new to everytime and I've learned something new and it keeps it interesting for me.Katie Couric: You've been doing this for the past five years, are you sick at it at all? And I mean do you feel like, Gee, I want to try something else or gosh, I'd like to be a normal teenage girl for a little while?Emma Watson: Well in between er, in between the films I was to have a break. Er...I go back school and I do the kind of a normal school girl, there for a...for a while which is nice and uhm, I stop on the fifth of Feburary and then after that, em, we will see, I definitly would want to be the last thing I do, I'm looking around for a new start. Yeah.Katie Couric: Emma Watson, it's always a pleasure to see you. ("Thank you~") Thanks so much for coming by and enjoying our cool Harry Potter set, right? Emma?("Yeh~ It's really good.") And Harry Potter and the Goblet of Fire hits theaters this Friday. 200807/45044ampliative ------ 扩展的(形容词) 英文释义(adjective) Describing something that adds to what is aly known. 例句 The scholars many publications are not particularly innovative; instead, they are ampliative narrations that extend understanding of previous theories.这位学者的很多著作缺乏独特的创新性,只是扩展性的论述,引伸了对之前的理论的理解。 /201610/4665208 保险费用3句英文任你选The extra premium insured is to be paid by the buyer.额外保险费由买方承担。The premium is calculated according to the premium rate or rates for risks to be covered.保险费是根据投保险别的保险费率计算的。The premium for insurance covering All Risks and War Risk will natura11y be higher than that covering WPA.投保综合险和战争险的保险费当然比投保水渍险的保险费高。半个句型要记牢premium(保险费)Tip:premium作名词时,有;溢价,过高价值;的意思,表示额外费用具体指保险,红利等,所以在保险业就指保险费,短语有pay a premium for (付…佣金)。还可作形容词,意思是;高级的,优质的,特级的,高价的;。If you are employed , your employer will pay most of the premium. (假如你有工作,你的雇主将承担你的大部分保费。) /201605/434147Famously generous with their bonuses but hard hit by the sub-prime mortgage crises, big investment banks are facing a dilemma this year---to reward or not to reward. Can the big banks get away with handing out chunky bonuses in the face of ailing profits? For more in this issue of end-of-year bonuses, I'm joined by Andrew Oliver. He is the managing director of executive search company Profile Search and Selection based right here in Hong Kong.Welcome to the program. End-of-the-year bonuses, it's a time fast approaching. What should we expect?Well, I think the short answer is that at the end of the year banks are gonna pay out enormous amounts of money. However, the subtext here is a little more complicated. These are vast institutions that rely on very, very diverse revenue streams by division and geography. And for some of the parts of the banks, they've had to start the year again in 2007. So how big a bonus will be handed out?Well, that's a very interesting question. I think it depends on where you are working and I suppose geographically and by division and also depends on whether you are a peak performer or you are not. I think this year we are gonna see some areas, when I say areas I mean geographies hit harder than others. And we're gonna see some divisions hit harder than others. But next year the banks are still gonna make money. They're still gonna carry and hold on to their peak performers. So people will get paid regardless.So how much is the cost to hold on to a peak performer?Well, I think the top 10, 15% regardless of the division area, will be paid at least flat or maybe up from last year. However, I think we're gonna see a polarization of bonuses this year. Peak performers will get paid because they've got to look at 2008.Give me a number, Andrew. Because I some place, it's an average of 200,000 US dollars. Does that sound right?Well, I mean the numbers that come out, you know, the numbers that come out are in my opinion sometimes a little bit misleading. Because you take, you know vast organizations, then divide the number by the number of employees. I think the people who are making the money, the key producers, within the key front line roles will still get paid.And they will get paid how much as a bonus?Well, I think if you look in percentage terms in 2006, that's probably a better indication. And I would say peak performers will still get paid more than they got paid last year.You are still not giving me a concrete number but they will still get paid. They will still get a big bonus. And this year was a notoriously bad year for the financial sector. How can banks justify, handing out such big bonuses during such a terrible year?Well, looking in the context, it's not been a terrible year. It's been a terrible few months. It's been a fairly terrible few months for certain part of very large institutions. Parts of the businesses have made a lot more money than they made last year. And part of the geographies around the world had made a lot more money than they made last year.So in terms of where the bonuses will come from, certain sectors of the bank will probably end up paying out the bonuses for the other players in the bank.Yes, there's always gonna be a little bit of, there’s always gonna be a little bit of cross-divisional support. However, I think you know, we'll see, you know, certain divisions that have been hit very hard by the sub-prime issues. Yes,they're gonna get hit hard in their bonuses. But yes, you know, certain divisions such as equities divisions or corporate finance divisions that have made a lot of fees and underwriting in the early part of this year will in some way support parts of the businesses that have been hit.But in a year, there have been layoffs, and I'm hearing of, of more layoffs to come. It's really an employer's market. Why is it even necessary to pay out big bonuses?Well, the people who run the organizations will have to run amid a commercial, in a commercial manner. They need to look at, looking after the people that're gonna make the money in 2008. Someone said to me it's sometimes very difficult to say, is it a retrospective reward for what you did last year or is it a reward for what you may do next year.That's the question. Andrew Oliver, thank you very much for joining us.Thank you.Notes: retrospective: Applying to or influencing the past200807/43587

Scripts:A: The Fed has got to cut rates , there’s no question.B: How much?A: Er.. I think what we need to see is er, a process of cutting rates, so it’s less about how much today and about the, the holding up the hope of more rate cuts to come, what I’m expecting is a quarter point of the Fed funds rate today. Er, half of a percent of the emergency discount rate that’s where banks go when they are in difficulties. But clearly, a statement which says more is going to come. Don’t worry, guys, we’ll keep on cutting.B: And what’s their key focus right now, is it trying to get the banks to er… reduce their inter-bank lending rate, is that the key focus right now?A: That’s part of the process. Er… but it’s slightly wider than that , because of course what you’ve got at the moment is actually a monetary policy tightening. You’re a consumer, your interest rate hasn’t come down 3 quarters of a point along with the Fed funds rate. If you are a consumer, the chances are your interest rate's gone up because banks are tightening credit standards, and raising the cost that they pass on to the consumer. So what the Fed is concerned to do is to stop that process of monetary policy tightening.B: And whatever the rates are , the other problem is the fact that the banks are just reducing their lending generally, and they don’t wanna lend to anyone with any sort of risky background, so that's gonna cause problem within itself. There is nothing the Fed can do about that, is there?A: No, there is not much that the Fed can do about that. Er…, at the margin, we are, I think going to less credit, now, I’m, we can go back to Japan in the, in the 1990s, it doesn’t matter how much you cut rates. You cannot force banks to lend if they don’t want to. But in actual fact, one of the things that we’re concerned about is not so much new borrowers, but existing borrowers who’ve got adjustable rate debt er… where the interest rates go up and down, those are the guys who are vulnerable in this current environment, and the Fed's got to try and limit the damage to them. Because of course there are far more existing borrowers than there are potential new borrowers.B: And you mentioned that the discount er.. rates which is the rate that the, you say that the banks go to the Feds asking for money if they really need it. Er… but that’s kind of epidemic, isn’t it? Because once people start using or once banks start using that facility, there is a huge stigma attached to that , so they are gonna avoid that , anyway, aren’ they?A: Well, there is a stigma, and particularly here in the ed Kingdom, er…borrowing from the Bank of England attaches a huge stigma. In the States it will…B: Northern Rock was the classic example.A: Precisely. In the ed States it’s less so, and there has been more willingness to borrow from the discount window er in the ed States. So,er…I think actually as the credits crisis of confidence continues, banks will get over the social stigma and recognize that, hold on, if here's someone prepared to lend his money. We might as well take advantage of it, and that will then help to at least smooth over some of the problems in the market...Notes: smooth over: To mitigate or alleviatediscount rate: The discount rate is the interest rate charged to commercial banks and other depository institutions on loans they receive from their regional Federal Reserve Bank's lending facility--the discount window.200807/43329

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